Druggists and retail – In addition to wholesaling, druggists in the early 19th century transformed the retail side of their business operations. Most druggists had always had some small retail sales–selling compact packages of drugs and spices. As commerce became more specialized in the early 1800s, druggists saw that their goods made an excellent mix for retail and opened up "front ends." Druggists commonly referred to their locations as "drug storehouses," or simply "drug stores." This was in direct contrast to the retail establishments of apothecaries, which were called "shops." The American public soon turned to calling all pharmacy-related businesses "drugstores" and their proprietors "druggists."
Drugs & Medicines in the Chests – Like almost all the items sold by Philadelphia druggists, the vast majority of drugs purchased by Lewis for the expedition were of foreign origin, traveling thousands of miles to reach the shelves of Gillaspy and Strong.
Although networks had existed since ancient times for trade in spices and drugs, many new medicines entered the Western materia medica during the sixteenth and seventeenth centuries.
Some arrived from new lands opened to the West through exploration, while others came out of the laboratories of chemists. Whether animal, vegetable, or mineral in origin, almost all the drugs sold by druggists and apothecaries in the young United States first passed through the hands of British importers.1
Cinchona Bark (Peru and Bolivia) – It was no accident that the largest amount of a single medicine purchased by Whelan for the Corps was fifteen pounds of "Pulv. Cort. Peru" otherwise known as cinchona bark or simply bark. One of the great panaceas of the era, cinchona bark arrived in Europe from South America in the early 1600s as a specific cure for intermittent fevers (malaria). As a specific it rocked traditional medical theories, which maintained that disease came from humoral imbalances within the body. As one of the few drugs that actually cured a disease, cinchona was soon tried against other fevers and many other constitutional ailments even though it had little if any effect.2
Quinine, the main active ingredient of cinchona bark was not isolated until 1820 by French pharmacists Pelletier and Caventou.3 Only ten or twelve ounces of this alkaloid would have equaled the medicinal power of the Corps' bulky container of powdered bark. The cinchona probably arrived in Philadelphia via London merchants, rather than directly from South America.
(Four of the top 100 drugs prescribed in 2002 were derived in part from opium, including the number one medicine, hydrocodone with acetaminophen.) And while opium and its preparations were used for the relief of pain, they were also the sedatives and hypnotics of choice two hundred years ago. About the same time as the Lewis and Clark Expedition, German pharmacist Friedrich Sertürner was developing the method to extract morphine from crude opium, thereby beginning the era of alkaloidal chemistry. As in the case of cinchona and quinine, however, this discovery would come too late for the Corps, which was required to take the bulkier crude drug along for the 8,000-mile journey.4
Lewis, as Jefferson's private secretary, may have read the following from the Edinburgh New Dispensatory, a book in the president's library:
Egypt, Persia, and some other provinces of Asia, have hitherto supplied us with this commonly: in those countries, large quantities of poppies are cultivated for this purpose. . . . Opium, when taken into the stomach . . . gives rise to a pleasant serenity of mind, in general proceeding to a certain degree of languor and drowsiness. . . . no substance can have a better title to the appellation of sedative than opium. . . . Indeed there is hardly any affection, in which it may not, from circumstances, be proper; and in all desperate cases, it is the most powerful means of alleviating the miseries of patients.5
Hypodermic syringes were a half-century in the future, so physicians of the early 19th century administered opium orally, often in the form of a simple rolled pill. As a valuable drug, opium was often adulterated, therefore druggists like Gillaspy and Strong carefully examined each shipment that arrived. Their reputation as dealers in quality drugs depended largely on the potency of their opium.6
Ipecac (Brazil) -- A drug sometimes combined with opium was ipecac, one of the most versatile medicines of the early modern period. Introduced into Western therapeutics in the late 1600s from South America, ipecacuanha quickly gained stature as a treatment for dysentery and as a reliable emetic and diaphoretic. Intentionally inducing vomiting or sweating was viewed at the time as a good way to alter the body's balance and encourage the restoration of health. Ipecac remains an official drug, although its status as an emergency emetic has declined in recent years. In 1803, most ipecac roots were dug in Brazil for exportation.7
Camphor (Sumatra) – Another exotic carried along by Lewis and Clark that is still official is camphor. One contemporary author described it as "a very peculiar substance . . . chiefly extracted from the wood and roots of a tree growing in Sumatra." The collection of camphor was described by Marco Polo and in the Arabian Nights. Considered a concrete essential oil, the drug was administered orally to combat fevers through inducing perspiration.8
Copaiba (Brazil and Venezuela) – Buried in the usual lists of medicines carried by the Corps of Discovery is "Balsam of Copaiba." This soothing liquid came from tapped trees in the Amazon basin. Although it had other applications, copaiba (pron. co-pie-buh) was mainly used for the treatment of gonorrhea. When consumed internally, it produced a characteristic odor to a patient's urine and was thought to soothe inflammation caused by venereal disease. As experienced army officers, Lewis and Clark knew they needed to be prepared to treat VD, so they brought along copaiba, calomel, and penile syringes.10
Asafetida (Iran and Afghanistan) – Of all the imported drugs, perhaps the most notorious was asafetida, also known as "devil's breath." This nasty smelling drug from Persia was known since ancient times. Widely consumed on the theory that anything that smelled that bad had to be good for something, asafetida's serious use by 1800 had declined to the treatment of nervous complaints and flatulence. Its folk use to ward off colds and flu continued into the twentieth century. Why the Corps took an entire pound of this smelly substance is unclear. There is no apparent record of it being used during the journey.
Columbo Root (Mozambique) – When Gillaspy and Strong packed up half a pound of columbo root for the Corps, they probably thought the drug came from Ceylon (modern Sri Lanka). For decades, Portuguese traders had a monopoly on this drug and hid its origins. Portuguese ships would stop on the East coast of Africa, purchase the roots from local gatherers, and then carry them along to India on their journeys before returning home to Europe. At first called kalumb, the drug's name shifted to variations of "colombo," the capital city of Ceylon. In the 1820s its origins were clarified. No matter what its name, columbo was never an important drug, and was probably included by Lewis as a tonic and restorative.11
Cinnamon (Sri Lanka), Nutmeg and Cloves (Moluccas) – Ceylon was the source for cinnamon, which like other spices were carried in the same ships, exchanged by the same dealers, and sold by apothecaries along with drugs.
For centuries there had been a fine line between these precious items. In both regular and folk medicine, pungent spices were taken to improve digestion. Some authors have speculated that Lewis bought the cinnamon, nutmegs, and cloves to flavor their drug preparations. It is just as likely that the captains bought them for culinary purposes. They could also have been used to prepare bait for beaver traps.12
Rhubarb (China) – Often conflated with the common culinary plant called rhubarb, Rheum or China Rhubarb was a botanical laxative with a long and distinguished history. Used as medicine since ancient times in China, the roots and rhizomes of rheum arrived in the West in the second century BC. Throughout the Middle Ages up to modern times, medicinal rhubarb was an active item of trade.13 By the time of Lewis and Clark, medicinal rhubarb was viewed as "a mild cathartic, which operates without violence or irritation. . . . In some people, however, it always occasions severe griping. Besides its purgative quality, it is celebrated for an astringent one, by which it strengthens the tone of the stomach and instines, and proves useful in diarrhoea." It was for this apparent dual activity that physicians valued rhubarb.14 Rhubarb remained an officially recognized drug for the next 150 years.15
Tragacanth (Persia) – A plant derivative that still finds use 200 years later is tragacanth. The dried gummy exudation from Astragalus gummifer or other species of Astragalus, tragacanth is used today as a "suspending agent in lotions, mixtures, and extemporaneous preparations and prescriptions."16 The captains could have used it as well to make up pill masses.17
1. Haynes, American Chemical Industry, 212.
2. Saul Jarcho, Quinine's Predecessor: Francesco Torti and the Early History of Cinchona (Baltimore: Johns Hopkins University Press, 1993). [Andrew Duncan] [WorldCat says William Lewis], The Edinburgh New Dispensatory (Philadelphia, T. Dobson, 1791), 250-254.
3. Friedrich A. Flückiger & Daniel Hanbury, Pharmacographia (London: Macmillan and Co., 1874), 320-321.
4. "2002 Rx Market: A Look in the Rear View Mirror," Drug Topics 147 (March 17, 2003): 37-38, 40, 44, 60, 62. Aaron J. Ihde, The Development of Modern Chemistry (New York: Harper & Row, 1964), 167.
5. Edinburgh New Dispensatory (1791), 240-243.
6. Jacob Bigelow, A Treatise on the Materia Medica, Intended as a Sequel to the Pharmacopoeia of the Untied States (Boston: Charles Ewer, 1822): 271-272; Freedley, Principal Trades, 149.
7. John Uri Lloyd, Origin and History of all the Pharmacopeial Vegetable Drugs, Chemicals and Preparations, Volume 1 (Cincinnati: Caxton Press, 1921): 168-176; Edinburgh New Dispensatory (1791), 211-213; Bigelow, Materia Medica, 232-234.
8. Lloyd, Pharmacopeial Vegetable Drugs, 39-40; Edinburgh New Dispensatory (1791), 156-157.
9. Felix Brotero (1744-1828) was the Portugese botanist who published the first official description of Cephaelis ipecacuanha.
10. Lloyd, Pharmacopeial Vegetable Drugs, 110-116; Bruce Paton, Lewis & Clark: Doctors in the Wilderness (Golden, CO: Fulcrum, 2001), 50-51.
11. Flückiger & Hanbury, 22-24; Edinburgh New Dispensatory (1791) 175-176.
12. Flückiger & Hanbury, Pharmacographia, 466-474, 451-456, 249, 255. Moulton, Journals, January 7, 10, 1806. Mace and vanilla were also said to be effective for this purpose. Ibid., January 10, 1806.
13. Flückiger & Hanbury, 442-451.
14. Edinburgh New Dispensatory (1791), 263-4.
15. National Formulary, 10th ed. (Washington, DC: American Pharmaceutical Association, 1955): 493. For an excellent study of this drug, see Clifford Foust, Rhubarb: The Wondrous Drug (Princeton, NJ: Princeton University Press, 1992).
16. David B. Troy, ed., Remington: The Science and Practice of Pharmacy (Philadelphia: Lippincott, 2006), 1076.
17. Edinburgh New Dispensatory (1797), 257.
18. Ibid.,196, 313.
18. Moulton, Journals, August 24, 1805.